Reference Libraries

August 16, 2021

Low-temperature plasma on peri-implant-related biofilm and gingival tissue

Background: Evaluate the effect of low-temperature plasma (LTP) on an anaerobic biofilm and on the biological response of an in vitro reconstituted gingival epithelium tissue. Methods: Porphyromonas gingivalis W83 biofilm was cultured on titanium discs and reconstituted gingival tissues were... Read More

July 14, 2021

A mixed community of skin microbiome representatives influences cutaneous processes more than individual members

Skin, the largest organ of the human body by weight, hosts a diversity of microorganisms that can influence health. The microbial residents of the skin are now appreciated for their roles in host immune interactions, wound healing, colonization resistance, and... Read More

June 24, 2021

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung 2 Epithelial Tissue Equivalents

Sever acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third coronavirus in less than 20 years to spillover from an animal reservoir and cause severe disease in humans. High impact respiratory viruses such a pathogenic beta-coronaviruses and influenza viruses, as well... Read More

June 24, 2021

Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin–liver microphysiological model

We used TissUse’s HUMIMIC Chip2 microfluidic model, incorporating reconstructed skin models and liver spheroids, to investigate the impact of consumer-relevant application scenarios on the metabolic fate of the hair dye, 4-amino-2-hydroxytoluene (AHT). After a single topical or systemic application of... Read More

June 16, 2021

Microvesicating effects of sulfur mustard on an in vitro human skin model

Bis-(b-chloroethyl) sulfide (SM) is a potent skin vesicant previously used for chemical warfare. Progress in determination of the mechanistic basis of SM pathology, and development of prophylactic and/or therapeutic countermeasures to SM exposure has been hampered by lack of physiologically... Read More