Watch our recent webinar on the development of an in vitro blood-brain barrier model for studying its impact on glioblastoma[Scroll down to video]
Glioblastoma is a formidable adversary, often leaving patients, oncologists, and researchers with limited options. The blood-brain barrier, a specialized vascular network, plays a crucial role in determining the effectiveness of therapies due to its selective permeability. In patients, this barrier is often compromised, which leads to increased challenges in treatment.
Modeling Blood-Brain Barrier and Glioblastoma in vitro
To study the role of the BBB in GBM tumorigenesis and therapy resistance, a complex in vitro model that mirrors the solid tumor morphology of GBM and its interaction with the surrounding BBB was developed using AIM Biotech’s organiX microfluidic culture plates. The model is amenable to a variety of downstream analyses including histology, flow cytometry and mass spectrometry, providing novel insight into the disease’s complexity.
Accelerating Therapeutic Breakthroughs
Discover groundbreaking findings that shed light on the active role of the BBB in GBM tumorigenesis and therapy resistance. Witness firsthand how this advanced model expedites the validation process for novel therapies, including cutting-edge approaches like CAR-T cell therapy.
Learn more about the organiX organ-on-a-chip platform
Watch the presentation!
Open Access Publication
Dr. Lam’s presentation is based on her work recently published in the journal Small, which focuses on science at the micro and nano scale, and is available as an open-access publication online.
Meet Our Presenter:
Maxine Lam, Ph.D.
Maxine studied in Singapore, and was awarded the A*STAR NSS BS-PhD scholarship. She graduated with a BSc in Natural Sciences, majoring in Genetics, at University of Wisconsin-Madison and was then accepted into the Wellcome Trust PhD program in Developmental and Stem Cell Biology at University College London, where she investigated the role of tissue tension on cell division using Drosophila as a model system. Maxine then did a short post-doc at the Institute of Cancer Research studying the role of cellular biomechanics in cancer extravasation, and is currently working on developing physiologically relevant 3D models for cancers. Connect on LinkedIn