Reference Libraries

December 11, 2015

GINGIVAL TISSUE MODEL FOR PREDICTION OF IRRITANCY OF ORAL CARE PRODUCTS.

The development of human reconstructed tissues of the oral cavity that express in vivo-like differentiated characteristics would be important to better understand and develop therapies for gum disease, oral cancer, lesions due to smokeless tobacco, and gingivitis, amongst other diseases... Read More

December 11, 2015

HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED IN VITRO TO CIGARETTE SMOKE AT THE AIR-LIQUID INTERFACE RESEMBLE BRONCHIAL EPITHELIUM FROM HUMAN SMOKERS.

Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, to develop new therapies, and to assess the biological perturbations induced by environmental pollutants. Herein, we investigate... Read More

December 11, 2015

CELLULAR RESPONSES OF PRIMARY HUMAN BRONCHIAL EPITHELIAL CELLS TO WHOLE CIGARETTE SMOKE EXPOSURE.

This study by researchers at GlaxoSmithKline (GSK) demonstrated that MatTek’s EpiAirway human airway in vitro tissue model combined with the Vitrocell system provided a more physiologically relevant model for studying the effects of cigarette smoke exposure. Rationale: Traditional approaches towards... Read More

December 11, 2015

INHIBITION OF MELANOSOME TRANSFER RESULTS IN SKIN LIGHTENING.

The chemical basis of melanogenesis is well documented, but the mechanism of melanosome transfer and the regulation of pigmentation by keratinocyte-melanocyte interactions are not well understood. Therefore we examined the effects of serine protease inhibitors on skin pigmentation and found... Read More

December 11, 2015

USE OF MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES TO STUDY MODULATORS OF SKIN PIGMENTATION.

There is considerable interest in developing both cosmetic and pharma-ceutical formulations which cause darkening or lightening of the skin. These products are utilized to cosmetically alter one’s natural skin color, to provide natural protection from UV irradiation (by increasing melanin... Read More

Reference Libraries

GINGIVAL TISSUE MODEL FOR PREDICTION OF IRRITANCY OF ORAL CARE PRODUCTS.

HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED IN VITRO TO CIGARETTE SMOKE AT THE AIR-LIQUID INTERFACE RESEMBLE BRONCHIAL EPITHELIUM FROM HUMAN SMOKERS.

CELLULAR RESPONSES OF PRIMARY HUMAN BRONCHIAL EPITHELIAL CELLS TO WHOLE CIGARETTE SMOKE EXPOSURE.

INHIBITION OF MELANOSOME TRANSFER RESULTS IN SKIN LIGHTENING.

USE OF MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES TO STUDY MODULATORS OF SKIN PIGMENTATION.

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