Reference Libraries

April 20, 2022

Primary Human Cell-Based 3D Colon Tissue Model for Toxicological Studies

The aim of this study was to reconstruct and characterize a primary cell based human 3D colon tissue model for the study of: 1) microbiome, 2) colorectal care product screening for their irritation potential, 3) safety and efficacy of anti-microbial... Read More

April 20, 2022

Organotypic 3D primary human nasal tissue model for toxicological studies

The nasal mucosa serves as the first line of defense against inhaled chemicals, drugs, and respiratory infections. Here we developed a novel in vitro primary human cell-based 3D human nasal epithelial tissue (NET) cultured on a cell culture insert with... Read More

April 4, 2022

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances

The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food additives and novel food ingredients. Micronucleus assays typically utilise homogenous in vitro cell lines which... Read More

April 4, 2022

Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome

An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report... Read More

February 22, 2022

Comparison of 3D airway models for the assessment of fibrogenic chemicals

Lung epithelial cells and fibroblasts play key roles in pulmonary fibrosis and are involved in fibrotic signaling and production of the extracellular matrix (ECM), respectively. Recently, 3D airway models consisting of both cell types have been developed to evaluate the... Read More