Reference Libraries

July 20, 2022

Regeneration of collagen fibrils at the papillary dermis by reconstructing basement membrane at the dermal–epidermal junction

The epidermal basement membrane deteriorates with aging. We previously reported that basementmembrane reconstruction not only serves to maintain epidermal stem/progenitor cells in the epidermis, but also increases collagen fibrils in the papillary dermis. Here, we investigated the mechanism of the... Read More

July 18, 2022

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

Microphysiological systems (MPS) aim to mimic the dynamic microenvironment and the interaction between tissues. While MPS exist for investigating pharmaceuticals, the applicability of MPS for cosmetics ingredients is yet to be evaluated. The HUMIMIC Chip2 (“Chip2′′ ), is the first... Read More

July 13, 2022

Anti-aging Effects of Retinoid Hydroxypinacolone Retinoate on Skin Models

Tretinoin, also known as all-trans retinoic acid (ATRA), has been well-known for its anti-aging effects on skin since the 1980s.1,2 ATRA functions by activating the nuclear retinoic acid family of receptors (RARs), which control gene transcription by binding to retinoic... Read More

July 13, 2022

2-kDa hyaluronan ameliorates human facial wrinkles through increased dermal collagen density related to promotion of collagen remodeling

Background/Aims: Hyaluronan (HA) oligosaccharides are involved in several biological processes, primarily collagen remodeling and wound healing. Collagen remodeling is retarded in aging skin and causes wrinkles. The aim of this study was to evaluate the effect of 2-kDa HA oligosaccharides... Read More

July 12, 2022

Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to one in five children and millions of adults in developed countries. Clinically, AD skin lesions manifest as subacute and/or chronic lichenified eczematous plaques, which are often intensely... Read More