Reference Libraries

December 11, 2015

APPROACHES FOR THE DEVELOPMENT OF CELL-BASED IN VITRO METHODS FOR CONTACT SENSITIZATION.

Allergic contact dermatitis (ACD) is a cell-mediated immune response to small molecular weight chemicals that contact and penetrate the skin. There are a variety of characteristics that determine whether a chemical can function as a contact sensitizer (or allergen) including... Read More

December 11, 2015

PLASMACYTOID DENDRITIC CELLS AS A TOOL FOR TESTING ALLERGENICITY OF CHEMICALS.

This study by MatTek Corp. scientists demonstrated that MatTek’s Human Dendritic Cells (DCs) contain both plasmacytoid DCs (pDC) and myeloid DCs (mDC), that they can be separated into those 2 cell populations, and that MatTek pDCs can be used to... Read More

December 11, 2015

HARVEST, PROLIFERATION, AND FUNCTIONAL TESTING OF HUMAN DENDRITIC CELLS.

Purpose: Difficulty in harvesting large numbers of cells, short survival time, and rapid phenotypic changes in culture have prevented the widespread use of human dendritic cells (DC) for many fundamental studies applicable to the initial stages of pharmaceutical discovery and... Read More

December 11, 2015

CYTOKINE RESPONSE OF THE EPIDERM SKIN MODEL TO TOPICALLY APPLIED IRRITANTS AND TOXICANTS.

EpiDerm™, MatTek Corporation’s in vitro reproduction of the human epidermis provides a convenient way in which toxicity and irritation potential of chemicals and physical stresses can be assessed. Derived from single strains of human keratinocytes, the model contains layers of... Read More

December 11, 2015

CYTOKINE AND LIPID MEDIATOR RELEASE FROM IN VITRO SKIN MODELS FOLLOWING DETERGENT TREATMENT OR PHYSICAL WOUNDING.

The purpose of the present work is to characterize two in vitro skin mod-els with regard to release of inflammatory cytokines and lipids under basal conditions and following chemical or physical damage. The two models evaluated are Skin2 (Advanced Tissue... Read More

Reference Libraries

APPROACHES FOR THE DEVELOPMENT OF CELL-BASED IN VITRO METHODS FOR CONTACT SENSITIZATION.

PLASMACYTOID DENDRITIC CELLS AS A TOOL FOR TESTING ALLERGENICITY OF CHEMICALS.

HARVEST, PROLIFERATION, AND FUNCTIONAL TESTING OF HUMAN DENDRITIC CELLS.

CYTOKINE RESPONSE OF THE EPIDERM SKIN MODEL TO TOPICALLY APPLIED IRRITANTS AND TOXICANTS.

CYTOKINE AND LIPID MEDIATOR RELEASE FROM IN VITRO SKIN MODELS FOLLOWING DETERGENT TREATMENT OR PHYSICAL WOUNDING.

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