Reference Libraries

December 11, 2015

COLCHICINE PROMOTES ANTIGEN CROSS-PRESENTATION BY MURINE DENDRITIC CELLS.

This study by researchers at the University of Texas Southwestern Medical Center demonstrated that MatTek’s Human Langerhans/Dendritic Cells are an excellent in vitro model for investigating and predicting the likely interactions of drugs (Colchicine) with human dendritic cells. Colchicine (COL)... Read More

December 11, 2015

SKIN SCIENCE: THE USE OF GENOMICS TOOLS IN SKIN CARE.

This study by scientists at Genemarkers LLC demonstrated that MatTek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to identify the human genes activated when anti-aging and anti-wrinkle cosmeceutical products are applied to the apical surface. Elina... Read More

December 11, 2015

EPSTEIN-BARR VIRUS ENCODED DUTPASE CONTAINING EXOSOMES MODULATE INNATE AND ADAPTIVE IMMUNE RESPONSES IN HUMAN DENDRITIC CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS.

We have recently demonstrated that Epstein-Barr virus (EBV)-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) modulates innate immunity in human primary monocyte-derived macrophages through toll-like receptor (TLR) 2 leading to NF-KB activation and the production of pro-inflammatory cytokines. Our previous depletion studies indicated... Read More

December 11, 2015

APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

Delivery of pharmaceuticals via inhalation is a potentially useful alternative to intravenous injection for drugs that are unstable or poorly absorbed after oral administration; for chronic disease conditions that require frequent administration: or therapeutics for which the airways are the... Read More

December 11, 2015

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

15-Hydroxyeicosatetraenoic acid (15[S]-HETE) is the predominate arachidonic acid (AA) metabolite produced by human tracheal/bronchial tissue. This product of the 15-lipoxygenase (15-LOX) enzyme is believed to play a significant role in human airway inflammation and respiratory diseases including cystic fibrosis and... Read More

Reference Libraries

COLCHICINE PROMOTES ANTIGEN CROSS-PRESENTATION BY MURINE DENDRITIC CELLS.

SKIN SCIENCE: THE USE OF GENOMICS TOOLS IN SKIN CARE.

EPSTEIN-BARR VIRUS ENCODED DUTPASE CONTAINING EXOSOMES MODULATE INNATE AND ADAPTIVE IMMUNE RESPONSES IN HUMAN DENDRITIC CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS.

APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

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