Langerveld, A. Genemarkers LLC.

This study by scientists at Genemarkers LLC demonstrated that MatTek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to identify the human genes activated when anti-aging and anti-wrinkle cosmeceutical products are applied to the apical surface. Elina Ambra-Lift Activates Genes that Promote Anti-Aging and Anti-Wrinkle Effects. The use of genomics to validate the biological effects is an innovative approach. The experimental study design utilizing the highly differentiated EpiDerm Full Thickness (EFT-400) skin model, allowed for testing of the final product rather than single ingredients. Elina Ambra-Lift, an organic product, naturally induced expression of genes that regulate anti-wrinkle and anti-aging effects in the skin including Collagen 7A1, 4A1 and 4A2, Anti-Oxidants, and Sirtuin-1 genes. Elina will use these data to increase her presence from a localized, Midwest market to a more prominent, national product leader. Future Studies will include testing of additional products. In addition, the experimental design can be modified to test other conditions or endpoints. For example: Protection from UV exposure or other types of damage and repair from damage caused by UV exposure or other conditions. Summary and Market Projection: Genomics testing methods will play a more prominent role in cosmeceutical product development and testing. This will be driven by changes in Federal guidelines for more stringent regulations on marketing claims and safety guidelines, consumer awareness and their demand for products with proven efficacy, and competition; keeping up with companies/products that are using “hard science” approaches in their product development.


Affymetrix Microarrays (Gene Chips), Anti-aging gene, Anti-oxidant genes, Biochemical marker of wrinkles, Collagen 4A1, Collagen 4A2, Collagen 7A1 (COL7A1), Cosmeceuticals, EFT-400, EpiDerm FT, Genomics, Interleukin 1 beta (IL-1beta), Interleukin 1 receptor antagonist (IL-1RN), Methallothionein 2, Sirtuin 1 (SIRT1), Skin firmness, Superoxide dismutase 2, Taqman Real Time PCR, Wrinkles

Materials Tested

Ambra Lift

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