Reference Libraries

December 11, 2015

INITIAL CHARACTERIZATION OF A NEW MODEL FOR DERMAL IRRITANCY TESTING.

A model of the human epidermis, EpiDerm™, based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK) has recently been introduced by MatTek Corporation. Cultured using serum free media in easily handled Millicell® CM (Millipore Corp.) cell culture inserts, the model... Read More
December 11, 2015

EXPRESSION OF PROLIFERATIVE AND INFLAMMATORY MARKERS IN A FULL-THICKNESS HUMAN SKIN EQUIVALENT FOLLOWING EXPOSURE TO THE MODEL SULFUR MUSTARD VESICANT, 2-CHLOROETHYL ETHYL SULFIDE.

Sulfur mustard is a potent vesicant that induces inflammation, edema and blistering following dermal exposure. To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT™, a commercially available... Read More
December 11, 2015

SAFETY EVALUATION OF NANOSILVER USING RECONSTRUCTED HUMAN GIT TISSUES

In our pilot study focused on safety evaluation of nanosilver three novel commercially available  reconstructed human  tissues were used for mimicking the human gastrointestinal tract (GIT). The evaluated endpoints included tissue viability, cytokine release and penetration of silver into the... Read More