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December 11, 2015

VAGINAL MICROBICIDE GEL FOR DELIVERY OF IQP-0528, A PYRIMIDINEDIONE ANALOG WITH A DUAL MECHANISM OF ACTION AGAINST HIV-1.

Pyrimidinediones, a novel class of compounds, have previously been shown to possess antiviral activity at nanomolar concentrations. One member of this class of compounds, IQP-0528, was selected as the lead molecule for formulation development owing to its stability at physiologically... Read More

December 11, 2015

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

This study by researchers at Boston University School of Medicine and MatTek Corp. demonstrated that the EpiVaginal full thickness human cervico-vaginal tissue equivalent can provide valuable information on molecular mechanisms of vaginal innate immunity, and serve as a test system... Read More

December 11, 2015

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

Three dimensional (3D) human vaginal-ectocervical tissue constructs may be a relevant in vitro model to rapidly screen for vaginal mucosal irritation potential of raw materials and final formulations. Here we report results from a study with an in vitro vaginal... Read More

December 11, 2015

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION.

The HIV/AIDS epidemic is continuing to escalate worldwide and it is estimated that through the year 2000, more than 34 million people have already been infected with the virus. Daily, 16,000 individuals acquire HIV-1 infection and the majority of all... Read More

December 11, 2015

PRECLINICAL EVALUATION OF UC781 MICROBICIDE VAGINAL DRUG DELIVERY.

UC781 is a potent nonnucleoside reverse transcriptase inhibitor being investigated as a potential microbicide to prevent transmission of HIV-1 both vaginally and rectally. This study was designed to investigate the in vitro drug release, in vitro permeability/safety, and in vivo... Read More

Reference Libraries

VAGINAL MICROBICIDE GEL FOR DELIVERY OF IQP-0528, A PYRIMIDINEDIONE ANALOG WITH A DUAL MECHANISM OF ACTION AGAINST HIV-1.

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

IN VITRO ASSESSMENT OF PERSONAL CARE PRODUCTS FOR VAGINAL IRRITATION USING 3D TISSUE CONSTRUCTS.

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION.

PRECLINICAL EVALUATION OF UC781 MICROBICIDE VAGINAL DRUG DELIVERY.

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