Reference Libraries

August 23, 2024

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

Ebola virus (EBOV) is the causative agent of the often-fatal Ebola virus disease (EVD) characterized by hemorrhagic fever in humans and non-human primates. Sexual transmission from male survivors has been at the origin of multiple outbreak flare-ups between 2015 and... Read More

August 23, 2024

In vitro prediction of the performance or equivalence, of different formulations of the same drug substance using a 3D reconstructed human intestinal tissue model: application to generics or drugs in development

“The BCS (Biopharmaceutics Classification System)-based biowaiver approach is intended to reduce the need for in vivo bioequivalence studies in Human, in order to lower costs of development, increase the market access for generic drugs and from an ethical point of... Read More

August 23, 2024

Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women

Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-grade human monoclonal antibodies (mAbs) for clinical use. We used the Nicotiana platform to produce... Read More

August 23, 2024

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal™ Tissue Model

The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely... Read More

August 23, 2024

In Vitro Irritation Assay and Regulatory Acceptance Two Years after ISO 10993-23:2021 Release

Medical device biological safety testing is transitioning away from the use of animals to more technologically advanced and reliable in vitro alternative methods. The irritation potential of medical devices has historically been evaluated by rabbit testing; however, ISO 10993-23:2021 offers... Read More

Reference Libraries

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

In vitro prediction of the performance or equivalence, of different formulations of the same drug substance using a 3D reconstructed human intestinal tissue model: application to generics or drugs in development

Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women

Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal™ Tissue Model

In Vitro Irritation Assay and Regulatory Acceptance Two Years after ISO 10993-23:2021 Release

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