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December 11, 2015

A CO-CULTURE MODEL OF THE AIR-BLOOD (ALVEOLAR) BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

Reliable in vitro human models for investigating airway toxicity are needed to advance Tox21 efforts to replace animal testing with human-based model systems. In vitro airway models based on primary human cells have been described. However, models based on animal... Read More

December 11, 2015

TERMINAL DIFFERENTIATION OF HUMAN KERATINOCYTES AND STRATUM CORNEUM FORMATION IS ASSOCIATED WITH CASPASE-14 ACTIVATION.

Programmed cell death of epidermal keratinocytes (KC) results in the formation of cornified cells, which constitute the outermost skin layer, the stratum corneum. Here we show by reverse transcription-polymerase chain reaction, western blot, and immunohistochemistry that epidermal KC express caspase-14,... Read More

December 11, 2015

GENE EXPRESSION PROFILING OF SKIN CARCINOGENSIS IN MICE.

This study by researchers at the University of Leicester and Unilever’s Safety Environmental Assurance Centre (SEAC) demonstrated that MatTek’s EpiDerm human skin tissue equivalents can be kept in a viable state for up to 23 DAYS. The overall goal of... Read More

December 11, 2015

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN, A NEW IN VITRO MODEL FOR SKIN CARCINOGENESIS STUDY.

EpiDerm (MatTek Co., MA) is a newly developed reconstituted human skin equivalent that exhibits human skin-like morphological and growth characteristics. It has been utilized to evaluate the cytotoxicity and irritant potential of various cosmetic and household products. In this study,... Read More

December 11, 2015

SULFUR MUSTARD-INDUCED RESPONSES OF AIRWAY AND SKIN IN VITRO.

Sulfur mustard (SM) is a vesicant that has been used in warfare and is a potential threat to civilians either from acts of terrorism or through accidental exposure to abandoned military caches of the chemical. Exposure of the skin produces... Read More

Reference Libraries

A CO-CULTURE MODEL OF THE AIR-BLOOD (ALVEOLAR) BARRIER RECONSTRUCTED FROM PRIMARY HUMAN CELLS.

TERMINAL DIFFERENTIATION OF HUMAN KERATINOCYTES AND STRATUM CORNEUM FORMATION IS ASSOCIATED WITH CASPASE-14 ACTIVATION.

GENE EXPRESSION PROFILING OF SKIN CARCINOGENSIS IN MICE.

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN, A NEW IN VITRO MODEL FOR SKIN CARCINOGENESIS STUDY.

SULFUR MUSTARD-INDUCED RESPONSES OF AIRWAY AND SKIN IN VITRO.

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