Reference Libraries

August 28, 2024

Toxicological Aspects of in vitro Oral Mucosa Wound Healing Models

Wounds in the oral cavity tissues can result from surgical procedures, accidents, and canker sores. Oral wounds present a site for potential infection and increased sensitivity to oral irritants. Untreated wounds can lead to pathogen invasion, chronic pain, poor cosmetic... Read More

August 28, 2024

Human 3D Colon Tissue Model for Toxicity and Microbiome studies

The human colon plays host to a wide variety of microbes living together in an ecosystem. Any damage or injury to the colonic epithelium disturbs this ecosystem which can in turn lead to inflammation and disease. The colonic epithelium is... Read More

August 28, 2024

Qualification of a non-animal vaginal irritation method admitted as nonclinical assessment model (NAM) in the Incubator Phase of the United States Food and Drug Administration (US FDA) Medical Devices Development Tool (MDDT)

The U.S. Food and Drug Administration (FDA) Center for Devices and Radiological Health (CDRH) classifies personal lubricants as Class II medical devices. Because of this status and the nature of body contact common to personal lubricants, CDRH reviewers routinely recommend... Read More

August 28, 2024

Aichivirus A1 replicates in human intestinal epithelium and bronchial tissue: Lung–gut axis?

The role of aichivirus A1 (AiV-A1) in acute gastroenteritis remains controversial and in vitro data illustrating its pathogenesis in suitable human models are scarce. Here, we demonstrate that AiV-A1 isolate A846/88 replicates in ApoA1- (absorptive) and Ki-67-positive (proliferative) enterocytes in... Read More

August 28, 2024

Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue

Inflammation plays a pivotal role in the development and progression of inflammatory bowel disease (IBD), by contributing to tissue damage and exacerbating the immune response. The investigation of serotonin receptor 2A (5-HT2A) ligands and transient receptor potential (TRP) channel ligands... Read More

Reference Libraries

Toxicological Aspects of in vitro Oral Mucosa Wound Healing Models

Human 3D Colon Tissue Model for Toxicity and Microbiome studies

Qualification of a non-animal vaginal irritation method admitted as nonclinical assessment model (NAM) in the Incubator Phase of the United States Food and Drug Administration (US FDA) Medical Devices Development Tool (MDDT)

Aichivirus A1 replicates in human intestinal epithelium and bronchial tissue: Lung–gut axis?

Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue

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