Reference Libraries

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

NON-ANIMAL METHODS FOR TOXICITY TESTING: EMERGING RESEARCH, METHODS & POLICIES.

Areas of emerging skin research include: studies on skin regeneration and the mechanisms involved in skin irritation and wound healing; modifying existing in vitro methods to make them acceptable for a broader range of testing applications; and, development of new... Read More

December 11, 2015

THE INCLUSION COMPLEX OF 4-HYDROXYNONENAL WITH A POLYMERIC DERIVATIVE OF Β-CYCLODEXTRIN ENHANCES THE ANTITUMORAL EFFICACY OF THE ALDEHYDE IN SEVERAL TUMOR CELL LINES AND IN A THREE-DIMENSIONAL HUMAN MELANOMA MODEL.

4-Hydroxynonenal (HNE) is the most studied end product of the lipoperoxidation process, by virtue of its relevant biological activity. The antiproliferative and proapoptotic effects of HNE have been widely demonstrated in a great variety of tumor cell types in vitro.... Read More

December 11, 2015

MELANODERM™: AN EPIDERMAL TISSUE MODEL CONTAINING FUNCTIONAL MELANOCYTES.

Organotypic skin models provide a useful, non-animal method of assessing the irritancy and efficacy properties of various cosmetic products. To address the modulation of skin pigmentation, MatTek Corporation has developed MelanoDerm™, a highly differentiated, three-dimensional tissue culture model of human... Read More

December 11, 2015

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN OF VARIOUS ETHNIC ORIGINS AS AN IN VITRO MODEL FOR STUDIES OF PIGMENTATION.

Reconstituted 3-dimensional human skin equivalents containing melanocytes and keratinocytes on an artifcial dermal substitute are gaining popularity for studies of skin metabolism because they exhibit morphological and growth characteristics similar to human epidermis. In this study, we show that such... Read More

Reference Libraries

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

NON-ANIMAL METHODS FOR TOXICITY TESTING: EMERGING RESEARCH, METHODS & POLICIES.

THE INCLUSION COMPLEX OF 4-HYDROXYNONENAL WITH A POLYMERIC DERIVATIVE OF Β-CYCLODEXTRIN ENHANCES THE ANTITUMORAL EFFICACY OF THE ALDEHYDE IN SEVERAL TUMOR CELL LINES AND IN A THREE-DIMENSIONAL HUMAN MELANOMA MODEL.

MELANODERM™: AN EPIDERMAL TISSUE MODEL CONTAINING FUNCTIONAL MELANOCYTES.

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN OF VARIOUS ETHNIC ORIGINS AS AN IN VITRO MODEL FOR STUDIES OF PIGMENTATION.

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