Reference Libraries

February 10, 2023

Safety assessment scheme for menstrual cups and application for the evaluation of a menstrual cup comprised of medical grade silicone

Background Ensuring menstrual cup safety is paramount, yet a menstrual cup safety assessment scheme is lacking. This paper presents a quadripartite scheme, showing how it can be applied. Methods The Tampax Menstrual Cup was evaluated in the safety assessment scheme:... Read More

February 9, 2023

Modeling of Ligand-Induced Acute and Chronic Inflammation in the gastrointestinal tract using In vitro 3D-human small intestinal microtissues

Intestinal epithelium is known to be involved in innate immune responses by recognizing potential pathogens through cellular pattern recognition receptors (PRRs). The purpose of this study is to investigate PRR responses following exposure of an in vitro 3D human small... Read More

January 13, 2023

Determination and Sub-categorization of Ocular Irritants Using the EpiOcular Tissue Model – Prediction Models for Liquids and Solids

Assessment of serious eye damage/eye irritation originally involved the use of laboratory animals (OECD TG 405). In 2015, a new test guideline (OECD TG 492) was accepted which enables the use of an in vitro procedure based on reconstructed human... Read More

January 13, 2023

Health safety of parabens evaluated by selected in vitro methods

Seven selected parabens (4 allowed, 3 banned in cosmetics) were tested in order to confirm and expand historical data on their toxicological properties and safety. The aim was to apply novel in vitro methods, which have been sufficiently technically and... Read More

December 27, 2022

Development of an oral mucosal irritation test using a three-dimensional human buccal oral mucosal model

The oral mucosa can become irritated by oral care products and lip cosmetics. Therefore, it is important to determine the irritation potential of their ingredients and products during safety evaluations. We developed a method for oral mucosal irritation test using... Read More