Reference Libraries

Information in the literature suggests that the most promising developments in in vitro ocular irritation assays are those involving 3-dimensional (3-D) models of the cornea1-5. In this study, the effects of materials of known ocular irritancy on two commercial models... Read More

Evaluating ocular irritation of eye-area cosmetics is essential to their safety assessment. Although eye-area formulations are designed to be mild, subjective/objective ocular responses can limit their acceptability. This study evaluated two similar formulations by comparing alternative assays, selected for their... Read More

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum-free medium. Haematoxylin and Eosin stained histological sections show the structure of EpiOcular to closely parallel that of the... Read More

A prospective validation study of two Reconstructed human Tissuebased in vitro test methods (EpiOcular™ EIT and SkinEthic™ HCE) was conducted by EURL ECVAM and Cosmetics Europe to evaluate their usefulness to identify chemicals as either not classified for serious eye... Read More

Colipa (European Cosmetics Association) is conducting an eye irritation programme for development of in vitro methods to replace the Draize rabbit eye test (now banned for evaluating cosmetic ingredients). This programme is focused on identification of new in vitro test... Read More