Reference Libraries

December 11, 2015

DEVELOPMENT OF A NEW IN VITRO GENETIC TOXICOLOGY MODEL USING RECONSTRUCTED HUMAN SKIN.

Choosing the Approach: • Procter & Gamble, a major cosmetics company, had excellent genetox personnel and expertise….and the idea to use a reconstructed skin model as a target tissue. • IIVS had extensive experience in using 3D skin models and... Read More

December 11, 2015

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

Determination of genotoxic potential is an important consideration for safety assessment of chemicals that may be inhaled following exposure to consumer products, occupational chemicals or environmental pollutants. Commonly used in vitro genotoxicity assays produce a high rate of false positive... Read More

December 11, 2015

ANALYSIS OF GLOBAL GENE EXPRESSION PROFILE CHANGES DURING THE DIFFERENTIATION OF THE EPIDERM™ IN VITRO HUMAN SKIN EQUIVALENT.

This study by researchers at Oxford University’s Wellcome Trust Centre for Human Genetics and the Oxford Centre for Gene Function demonstrated how MatTek’s EpiDerm in vitro human skin tissue equivalent can be used to provide a working knowledge of normal... Read More

December 11, 2015

EVALUATION OF THE EPIOCULAR TISSUE MODEL AS AN ALTERNATIVE TO THE DRAIZE EYE IRRITATION TEST.

Cosmetic ingredients were tested to determine the ability of the EpiOcular™ tissue model to predict eye irritation potential. In vitro results were compared with historical Draize eye irritation records. Forty-three samples, consisting of 40 cosmetic raw ingredients of different type... Read More

December 11, 2015

EPIOCULAR PREDICTION MODEL. A REPRODUCIBLE IN VITRO TISSUE CULTURE MEANS OF PREDICTING DRAIZE SCORES.

The EpiOcular™ tissue model (OCL-200) is an organotypic model of the human corneal epithelium (HCE) cultured from normal human keratinocytes using serum free medium. Parafin embedded, H&E stained histology cross-sections show the structure of EpiOcular closely parallels that of the... Read More

Reference Libraries

DEVELOPMENT OF A NEW IN VITRO GENETIC TOXICOLOGY MODEL USING RECONSTRUCTED HUMAN SKIN.

ASSESSMENT OF AIRWAY GENOTOXICITY POTENTIAL USING THE EPIAIRWAY IN VITRO HUMAN AIRWAY MODEL AND THE COMET ASSAY.

ANALYSIS OF GLOBAL GENE EXPRESSION PROFILE CHANGES DURING THE DIFFERENTIATION OF THE EPIDERM™ IN VITRO HUMAN SKIN EQUIVALENT.

EVALUATION OF THE EPIOCULAR TISSUE MODEL AS AN ALTERNATIVE TO THE DRAIZE EYE IRRITATION TEST.

EPIOCULAR PREDICTION MODEL. A REPRODUCIBLE IN VITRO TISSUE CULTURE MEANS OF PREDICTING DRAIZE SCORES.

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