Reference Libraries

December 11, 2015

Characterization of a Hormone-Responsive Organotypic Human Vaginal Tissue Model: Morphologic and Immunologic Effects

Estrogen and progesterone regulate proliferation and differentiation of epithelial cells in the female genital tract. We investigated the effects of these hormones on reconstructed human organotypic vaginal epithelial tissue models (EpiVaginal). We ascertained that epithelial cells in the tissue models... Read More

December 11, 2015

A RECOMBINANT SIALIDASE FUSION PROTEIN EFFECTIVELY INHIBITS HUMAN PARAINFLUENZA VIRAL INFECTION IN VITRO AND IN VIVO.

Background: The first step in infection by human parainfluenza viruses (HPIVs) is binding to the surface of respiratory epithelial cells via interaction between viral receptor-binding molecules and sialic acid–containing receptors. DAS181, a recombinant sialidase protein containing the catalytic domain of... Read More

December 11, 2015

TRICHOMONAS VAGINALIS LIPOPHOSPHOGLYCAN TRIGGERS A SELECTIVE UPREGULATION OF CYTOKINES BY HUMAN FEMALE REPRODUCTIVE TRACT EPITHELIAL CELLS.

This study by researchers at Brigham and Women’s Hospital/Harvard Medical School, Cornell University, Boston University School of Medicine, and SUNY Upstate Medical University demonstrated that MatTek’s EpiVaginal human cervico-vaginal tissue equivalent can be used to study in vitro the molecular... Read More

December 11, 2015

TRANSFER OF IgG IN THE FEMALE GENITAL TRACT BY MHC CLASS I-RELATED NEONATAL FC RECEPTOR (FCRN) CONFERS PROTECTIVE IMMUNITY TO VAGINAL INFECTION.

IgG is a major Ig subclass in mucosal secretions of the human female genital tract, where it predominates over the IgA isotype. Despite the abundance of IgG, surprisingly little is known about where and how IgG enters the lumen of... Read More

December 11, 2015

IN VITRO MODEL FOR IMMUNOTOXICITY: SURFACE MARKER EXPRESSION AND CYTOKINE RELEASE IN NORMAL HUMAN DENDRITIC CELLS (DC-100).

Dendritic cells (DC) play a key role in the initiation of immune response by recognizing, internalizing, processing, and presenting antigens to T cells. However, DC function can be altered by environmental factors, pharmaceutical agents, and exogenous chemicals. These perturbations to... Read More

Reference Libraries

Characterization of a Hormone-Responsive Organotypic Human Vaginal Tissue Model: Morphologic and Immunologic Effects

A RECOMBINANT SIALIDASE FUSION PROTEIN EFFECTIVELY INHIBITS HUMAN PARAINFLUENZA VIRAL INFECTION IN VITRO AND IN VIVO.

TRICHOMONAS VAGINALIS LIPOPHOSPHOGLYCAN TRIGGERS A SELECTIVE UPREGULATION OF CYTOKINES BY HUMAN FEMALE REPRODUCTIVE TRACT EPITHELIAL CELLS.

TRANSFER OF IgG IN THE FEMALE GENITAL TRACT BY MHC CLASS I-RELATED NEONATAL FC RECEPTOR (FCRN) CONFERS PROTECTIVE IMMUNITY TO VAGINAL INFECTION.

IN VITRO MODEL FOR IMMUNOTOXICITY: SURFACE MARKER EXPRESSION AND CYTOKINE RELEASE IN NORMAL HUMAN DENDRITIC CELLS (DC-100).

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