Skin Lightening

Considerable interest exists in evaluating cosmetic and/or skin care pharmaceutical formulations which cause lightening of the skin. These products are utilized to cosmetically alter one’s natural skin color or to combat skin pigmentation disorders such as melasma, post-inflammatory hyperpigmentation, and other hyperpigmentation lesions.

The use of MelanoDerm skin lightening assay provides invaluable in vitro data as an early screening tool for raw materials prior to the commencement of costly clinical trials.

MatTek offers MelanoDerm Skin Lightening/melanogenesis assay as a non-GLP service.

Protocol

Test Model	MelanoDerm
Replicates	N=8 tissues per test condition
Exposure Conditions	3 treatments/week for 2 weeks with 25µl of test material and controls
Assay Controls	2% Kojic Acid (positive control), DI H₂O (negative control)
Endpoints	Macroscopic analysis, Histological analysis, Quantitative Melanin Assay
Data Delivery	Histological images and analysis, Melanin Assay Analysis, Macroscopic photos Skin lightening potential