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NALTREXONE ESTER PRODRUG BIOCONVERSION IN A HUMAN EPIDERMIS EQUIVALENT.

Stinchcomb1, A., Hammell1, D., Challapalli1, P., Paxton1, E., Swaan2, P., Klausner3, M., 1University of Kentucky College of Pharmacy, Lexington, KY, 2The Ohio State University College of Pharmacy, Columbus, OH, 3MatTek Corporation, Ashland, MA.
Keywords

Bioconversion, Drug delivery, EpiDerm, Lipophilic alkyl ester prodrugs, Metabolism, Metabolite, Metabolize, NTxol, Naltrexol, Naltrexone, Percutaneous absorption, Permeability, Skin diffusion, Topical, Transdermal, Transdermal delivery, Transdermal drug delivery

Materials Tested

NTX, NTxol, Naltrexol, Naltrexone

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