In vitro and in vivo evaluation of a moisture treatment cream containing three critical elements of natural skin moisturization
Objectives: To evaluate skin barrier and hydration effects of a new rebalancing moisture treatment (TRMT) and to assess efficacy and tolerability in subjects with photodamaged skin.
Methods: In an epidermal skin model, tissues (n = 5/group) were topically treated with 25 μL of TRMT, 25 μL of a market-leading moisturizer (MLM), or untreated for 60 minutes. Hydration was measured at 0, 15, and 30 minutes. Tissues were harvested for gene expression analysis of markers associated with skin barrier and hydration: Claudin (CLD), Aquaporin (AQP), Hyaluronic Acid Syntheses (HAS), and Hyaluronidase (HYAL). A clinical study evaluated twice-daily application of TRMT, as- sessing changes in fine lines/wrinkles, brightness, texture, erythema, and tolerability from baseline through week 8. Hydration was measured using electrical impedance.
Results: TRMT and MLM demonstrated significant increases in hydration vs untreated tissue at each timepoint (P < .005), with greater hydration effects observed for TRMT vs MLM. TRMT-treated tissues demonstrated greater expression of CLD, AQP, and HA, and reduced expression of HYAL vs untreated and MLM-treated tissues. Twice-daily application of TRMT demonstrated significant improvements at 2 weeks in fine lines/wrinkles (P < .001), brightness (P < .0001), texture (P < .0004), and hydration (P < .004). At 8 weeks, statistically significant improvements were achieved in all categories.
Conclusion: In an epidermal skin model, TRMT demonstrated significant increases in hydration, greater hydration effects, and expression of key markers associated with skin barrier and hydration vs a MLM. Twice-daily application of TRMT was well tolerated and resulted in early, significant improvements in hydration and visible improvements in skin brightness, texture, fine lines/wrinkles, and erythema at 8 weeks.
EpiDerm-FT (EFT-400),Claudin (CLD), Aquaporin (AQP), Hyaluronic Acid Syntheses (HAS), Hyaluronidase (HYAL), skin hydration, electrical impedance, Nova Meter., Sodium PCA, Salicornia herbacea extract, Carnosine , Sodium lactate, Ceramide 1, Ceramide 3, Linoleic acid, Linolenic acid, Carnitine, Squalene, Aminopropyl ascorbyl phosphate, Sodium lactate, Sodium hyaluronate, Glycerin, Caffeine, Jojoba esters Skin Rejuvenation, Skin Aging, Skin Cream
Sodium PCA, Salicornia herbacea extract, Carnosine , Sodium lactate, Ceramide 1, Ceramide 3, Linoleic acid, Linolenic acid, Carnitine, Squalene, Aminopropyl ascorbyl phosphate, Sodium lactate, Sodium hyaluronate, Glycerin, Caffeine, Jojoba esters
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