4114

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.

Xuefen Xie, Michael S. Brown, John M. Shelton, James A. Richardso, Joseph L. Goldstein, and Guosheng Liang University of Texas Southwest Medical Center PNAS 108 (37) (2011)
Citation in paper containing MatTek reference "35-mm glass-bottom dish (MatTek, catalog no. P35G-1.5-14-C)"
Keywords

Cholesterol binding domain, cyclodextrin, knockin mutation, lysosomal storage disease, Niemann-Pick disease

Microscopic Technique

Immunofluorescence

Cell Line

fibroblasts

Part Number

P35G-1.5-14-C

Link to Paper