Skin irritation and potential efficacy of a novel compound for localized treatment of psoriasis
Psoriasis is a chronic condition characterized by formation of white scaly patches on the skin. Current treatment options include topical glucocorticoids which have several side effects. Pentaerythritol tetrakis (3,5-di-tert-butyl-4-hydroxyhydrocinnamate) (PTTC) is a cinnamate tetraester which may be used as a novel topical treatment for psoriasis with less side effects. The purpose of this study was to determine the skin irritation and potential efficacy of PTTC using in vitro cell culture models.
Skin irritation, psoriasis, IL-6, oil-in-water emulsion, SOR-300-FT, MTT, proteosome inhibitor
Cinnamate tetraester, Pentaerythritol tetrakis, 3,5‐di‐tert‐butyl‐4‐hydroxyhydrocinnamate, oil-in-water emulsion, sodium dodecyl sulfate (5%)
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