DNA photoprotection conveyed by sunscreen

Charlene DeHaven, MD,1 Patrick J Hayden, PhD,2 Alexander Armento, MS,2 & Jonathan Oldach, BS2.  1Innovative Skincare, Burbank, California, USA 2MatTek Corp., Ashland, Massachusetts, USA (2014)

Introduction:  Skin photoaging is the consequence of solar UV exposure, and DNA damage is an important part of this process. The objective of the current work was to demonstrate that in vitro skin models can be utilized to confirm that DNA damage protection is provided by sunscreens. Methods:   Skin equivalents were exposed to full-spectrum UV light administered with a standard research solar simulator with and without pre-application of sunscreen. Cyclopyrimidine dimer (CPD) and sunburn cell (SBC) formation as well as CPD quantitation were evaluated to determine DNA damage protection provided by the sunscreen. Results:  Marked decreases in both CPDs and SBCs were observed when sunscreen was applied prior to UV exposure. Conclusions:  Sunscreen application prior to full-spectrum solar UV exposure protects DNA from photodamage measured by CPD and SBC formation. This can be expected to lessen the risk of photoaging and malignant transformation.


Skin photoaging, photoprotection, sunscreens, DNA damage, apoptosis, cyclopyrimidine dimer, sunburn cell, EpiDerm-FT (EFT-306), DNA protection

Materials Tested

Sunscreens, full-spectrum UV light, zinc oxide, octinoxate, Tocopherol, Aloe, Olive leaf extract, Centella asiatica, botanical extremozymes

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