Dermal

Anti-Aging

Examine changes in extracellular matrix gene and protein expression and histological structure to determine the anti-aging efficacy of cosmetic ingredients or final formulation. EpiDermFT is available from a range of adult donors.

Anti-Melanoma Drug Screening

Mattek’s Melanoma tissue exhibits radial growth phase, vertical growth phase, and metastatic melanoma phenotypes, paralleling the progression of melanoma in vivo.

Anti-Psoriasis Drug Screening

The Psoriasis model provides researchers with a useful, in vitro means to assess the pre-clinical safety and efficacy of lead therapeutic compounds.

Dermal Drug Delivery

Utilize existing transdermal permeation equipment or Mattek’s simple single insert permeation devices to assess API permeation and flux. Determine relative safety with the EpiDerm MTT ET-50 assay.

Genotoxicity

Identify genotoxic effects of topical or systemic test substances using EpiDerm Genotoxicity Assays (pre-validated)

Phototoxicity (OECD TG 498)

Identify phototoxic effects of topical or systemic test substances using the EpiDerm Phototoxicity Assay (pre-validated).

Pigmentation Studies

MelanoDerm has been used to study the physiological mechanisms of skin pigmentation.

Skin Brightening

A quantitative assay to determine melanin content in the tissue is performed using the SOLVABLE™ melanin assay. This assay can be used to test the skin brightening efficacy of final cosmetic formulations.

Skin Corrosion (OECD TG 431)

Determine the skin corrosion potential of test materials in a single day.

Skin Hydration

Measure the electrical impedance of EpiDerm to assess the efficacy of topically applied moisturizers including creams, gels and lotions. The Skin Hydration protocol allows for data analysis within 24 hours.

Skin Irritation (MTT ET-50)

Use EpiDerm to determine the skin irritation potential of chemicals or formulations including liquids, solids, gels, lotions, ointments or creams. Skin irritation results are acquired within 3 days.

Skin Irritation (OECD TG 439)

Use EpiDerm to determine the skin irritation potential of chemicals or formulations including liquids, solids, gels, lotions, ointments or creams. Skin irritation results are acquired within 3 days.

Skin Irritation for Medical Device Extracts (ISO 10993-23:2021)

Tumor Invasion

Mattek’s Melanoma tissue exhibits radial growth phase, vertical growth phase, and metastatic melanoma phenotypes, paralleling the progression of melanoma in vivo.