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472.

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SAFETY STUDY OF AN ANTIMICROBIAL PEPTIDE LACTOCIN 160, PRODUCED BY THE VAGINAL LACTOBACILLUS RHAMNOSUS. Dover1,2, S.E., Aroutcheva3,4, A.A., Faro5, S., and Chikindas2,4, M.L. 1School of Biotechnology, The Royal Institute of Technology, 100 44 Stockholm, Sweden. 2Rutgers, The State University of New Jersey, New Brunswick, NJ 08901-8520, USA. 3Rush Medical Center, Chicago, IL 60612, USA. 4Health Promoting Naturals, Inc., Highland Park, NJ 08904, USA. 5The Women’s Hospital of Texas, Houston, TX 77054, USA. Infect. Diseases in Obstetrics and Gynecology (2007).

469.

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STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL™ MODEL. Anderson1, D., Nadolski1, A., Xu1, C., Pudney1, J., Politch1, J., Viglianti1, G., Bowman1, F., Ayehunie2, S., and Klausner2, M. 1Boston University School of Medicine, Boston, MA and 2MatTek Corporation, Ashland, MA. Microbicides 2008.

453.

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STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL SYSTEM. Anderson, D., Xu, C., Pudney, J., Nadolski, A., Viglianti, G., Bowman, R., Ayehunie, S., and Klausner, M. MatTek Corporation, Ashland, MA, USA.

431.

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THE RETROCYCLIN ANALOGUE RC-101 PREVENTS HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION OF A MODEL HUMAN CERVICOVAGINAL TISSUE CONSTRUCT. Cole1, A.L., Herasimtschuk1, A., Gupta2, P., Waring3, A., Lehrer3, R., and Cole1, A.M. 1Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett College of Biomedical Sciences at University of Central Florida, Orlando, FL, 2Department of Infectious Diseases and Microbiology, University of Pittsburgh, PA, and 3Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA. Immunology, (online edition), 23-Jan-2007.

430.

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TRICHOMONAS VAGINALIS LIPOPHOSPHOGLYCAN TRIGGERS A SELECTIVE UPREGULATION OF CYTOKINES BY HUMAN FEMALE REPRODUCTIVE TRACT EPITHELIAL CELLS. Fichorova1, R., Trifonova1, R., Gilbert2, R., Costello3, C., Hayes4, G., Lucas4, J., and Singh4, B. 1Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; 2Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY; 3Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA; and 4Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY. Infection and Immunity, 74, 10, 5773–5779, October (2006)

426.

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IRRITATION TESTING OF CONTRACEPTIVE AND FEMININE-CARE PRODUCTS USING EPIVAGINAL™, AN IN VITRO HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL. Ayehunie, S., Hayden, P., Cannon, C., Lamore, S., Klausner, M., Sheasgreen, J. MatTek Corporation, Ashland, MA. Presented at EUROTOX 2006, Cavtat and Dubrovnik, Croatia, September 20-24, (2006).

421.

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VISUALIZING INDIVIDUAL, FLUORESCENTLY TAGGED HIV-1 VIRIONS IN CERVICAL TISSUE. Hope, T., Schmidt, T., Forde, E. Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL. Presented at Microbicides 2006, Cape Town, South Africa, April 23-26, (2006).

420.

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BIOCOMPATIBILITY OF SOLID DOSAGE ANTI-HIV-1 MICROBICIDES AND VAGINAL PRODUCTS WITH THE MUCOSAL CYTOKINE NETWORK. Trifonova, R., Pasicznyk, J-M., Fichorova, R. Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Boston, MA. Antimicrobial Agents and Chemotherapy, 50, (12), 4005-4010, (2006).

418.

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EXPRESSION AND FUNCTION OF BACTERICIDAL/PERMEABILITY -INCREASING PROTEIN IN HUMAN GENITAL TRACT EPITHELIAL CELLS. Canny1, G., Trifonova2, R., Kindelberger3, D., Colgan1, S., Fichorova2, R. 1Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Boston, MA, 2Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Boston, MA, 3Cytology Division and Women’s and Perinatal Pathology Division, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. The Journal of Infectious Diseases, 194, 498-502, (2006).

411.

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CATIONIC POLYPEPTIDES ARE REQUIRED FOR ANTI-HIV-1-ACTIVITY OF HUMAN VAGINAL FLUID. Venkataraman, N., Cole, A.L., Svoboda, P., Pohl, J., Cole, A.M. Biomolecular Science Center, University of Central Florida, Department of Molecular Biology and Microbiology, Orlando, FL. The Journal of Immunology, 2005, (175) 7560-7567 (2005).

388.

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ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS. Ayehunie1, S., Cannon1, C., Lamore1, S., Kubilus1, J., Anderson2, B., Pudney2, J., Klausner1, M. 1MatTek Corporation, Ashland, MA, United States; 2Boston University School of Medicine, Boston, MA, United States. In Vitro Toxicology, 5, 689-698, (2006). Also presented at 45th Annual Society of Toxicology Meeting, San Diego, CA, March 5-9, (2006).

376.

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HUMAN VAGINAL—ECTOCERVIAL TISSUE MODEL TO TEST THE IRRITATION POTENTIAL OF CONTRACEPTIVE AND VAGINAL-CARE PRODUCTS. Ayehunie, S., Cannon, C., Lamore, S., Klausner, M., Sheasgreen, J., MatTek Corporation, Ashland, MA, USA. Presented at 5th World Congress, Berlin, Germany, August, (2005).

375.

VAGINAL FORMULATION - HOW INNOCUOUS ARE THEY TO THE VAGINAL EPITHELIAL IMMUME FUNCTION? Trifonova, R.T., Pasicznyk, J.M., Fichorova, R.N. Harvard Medical School, Department of Obstetrics and Gynecology, Boston, M.A, USA. Presented at 25th Anniversary Meeting of the American Society of Reproductive Immunology, Providence, RI, June 16-18, 2005. American Journal of Reproductive Immunology, 54, (2), 121, (2005).

321.

CONCORDANCE BETWEEN DIFFERENT IN VITRO CULTURE MODELS DESIGNED TO PREDICT VAGINAL IRRITATION AND/OR TOXICITY. Watts, P., Nuttall1, J., Coplan1, P., Fairhurst1, D., Mitchnick1, M., and Shattock, R. St. George’s Hospital Medical School, London, UK, and 1International Partnership for Microbicides (IPM), Silver Spring, MD, USA. Presented at Microbicides 2004, London, England, March 28-31, (2004).

320.

HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR MICROBICIDE IRRITATION STUDIES. Ayehunie1, S., Cannon1, C., Lamore1, S., Bellavance1, K., Kubilus1, J., LaBonte2, J., Owens2, C., Pudney3, J., Anderson2, D., Sodroski2, J., Klausner1, M. and Sheasgreen1, J. 1MatTek Corporation, Ashland, MA. 2Dana Farber Cancer Institute, Boston, MA. 3Brigham and Women’s Hospital, Boston, MA. Presented at Microbicides 2004, London, England, March 28-31, (2004).

312.

EVALUATION OF RECONSTITUTED HUMAN VAGINAL EPITHELIUM AS A MODEL FOR DRUG DELIVERY OF FLUCONAZOLE GEL FOR TREATING VULVOVAGINAL CANDIDIASIS. R. Elkeeb, M. Zdanowicz, and A. Belmonte. Massachusetts College of Pharmacy and Health Sciences, Boston, MA. Poster presented at the American Association of Pharmaceutical Scientists (AAPS), Salt Lake City, UT, October 26-30, (2003).

291.

RECONSTRUCTED HUMAN VAGINAL-ECTOCERVICAL TISSUE MODELS. Ayehunie1, S., Cannon1, C., Lamore1, S., Bellevance1, K., Kubilus1, J., LaBonte2, J., Pudney3, J., Anderson3, D., Sodroski2, J., and Klausner1, M. 1MatTek Corporation, Ashland, MA, 2Dana Farber Cancer Institute, and 3Brigham and Women Hospital, Boston, MA, USA. Presented at symposium entitled: "Topical Microbicides Development and Evaluation Workshop," The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Washington, D.C., Poster # A21, March 18-20, (2003).

266.

ORGANOTYPIC ECTOCERVICO-VAGINAL TISSUE MODEL CONTAINING DENDRITIC CELLS. Ayehunie1, S., Cannon1, C.L., Lamore1, S., Kubilus1, J., LaBonte2, J., Pudney3, J., Anderson3, D., Sodroski2, J., and Klausner1, M. 1MatTek Corporation, Ashland, MA 01721, 2Dana Farber Cancer Institute, and 3Brigham and Women's Hospital, Boston, MA, U.S.A. Presented at Microbicide 2002 Meeting, Antwerp, Belgium, May (2002).

255.

HUMAN TISSUE MODEL FOR VAGINAL IRRITATION STUDIES. Kubilus1, J., Cannon1, C.L., Klausner1, M., and Lonardo2, E.C. 1MatTek Corp., Ashland, MA., 2Johnson & Johnson, Personal Products Company, Skillman, NJ. The Toxicologist, 66 (1-S), 378, Soc. of Toxicol. (Reston, VA), Abstract #1848, (2002).

246.

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION. Ayehunie1, S., Cannon1, C.L., Kubilus1, J., Pudney2, J., LaBonte3, J., Anderson2, D., Sodroski3, J., and Klausner1, M. 1MatTek Corp., Ashland, MA 01721. 2Brigham and Womens Hospital, 3Dana Farber Cancer Institute, Boston, MA. Presented at Nobel Symposium No. 119, Global HIV Therapeutics - HIV Vaccines, Nobel Forum - Karolinska Instituet, Stockholm, Sweden, June 7-9, (2001).



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