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MatTek Corporation 200 Homer Avenue Ashland, MA 01721 508-881-6771 FAX: 508-879-1532 E-mail Us

EpiDerm™ Gene Analysis

A representative list of EpiDerm genes that have been analyzed are listed in table below.

Purified Total RNA from EpiDerm part numbers EPI-200 and EPI-200-HCF is now available. Each lot of RNA is characterized and provided with a quality control spec sheet including histology and Triton ET50 of the specific tissue lots, agarose gel electrophoresis of total RNA, RNA concentration, 260/280 ratio, results of G3PDH RT-PCR and TAQ-only PCR amplifications.

Control (untreated), simulated solar UVA, solar UVA+UVB and phorbol ester treated EpiDerm RNAs are available.

Inquire about pricing and other custom treatments.

Genes Analyzed To-Date	Tech Ref No.
constitutive nitric oxide synthase (cNOS)
Cyclooxygenase-1 (COX-1)	235, 260
Cyclooxygenase-2 (COX-2)	235, 260
glyceraldehyde-3-phosphate dehydrogenase (G3PDH)	235, 132
GM-CSF
23-kDa highly basic protein
inducible nitric oxide synthase (iNOS)	261
Intercellular adhesion molecule-1 (ICAM-1)	261
Interleukin-1 alpha (IL-1α)	132
Interleukin-1 beta (IL-1β)	132
Interleukin-6 (IL-6)	132
Interleukin-8 (IL-8)	132
Interleukin-15 (IL-15)
Interleukin-20 (IL-20)	261
Interleukin-20 Receptor alpha
Interleukin-20 Receptor beta
5-Lipoxygenase
12-Lipoxygenase
15-Lipoxygense-1
15-Lipoxygense-2
Placenta growth factors 1 and 2 (PLGF)	235, 197
Ribosomal protein S9
Thymus- and activation-regulated chemokine (TARC)	235
Tumor necrosis factor alpha (TNF-α)	132
Vascular endothelial growth factor-A (VEGF-A)
Vascular endothelial growth factor-B (VEGF-B)
Vascular endothelial growth factor-C (VEGF-C)
Vascular endothelial growth factor-D (VEGF-D)

Please contact MatTek for further information regarding treatment conditions, primer squences and PCR conditions for specific genes of interest.

	Psoriasis Tissue
	Dendritic (Langerhans) Cells
	EpiAirway Normal Human Airway Tissue Model
	EpiDerm Reconstructed Human Epidermis (RhE) Tissue Model
	EpiDerm-201 Under-developed Skin Model
	EpiDermFT™ Skin Model
	EpiOcular Normal Human Corneal Tissue Model
	EpiOral Normal Human Buccal, EpiGingival Normal Human Gum Tissue Models
	EpiVaginal Normal Human Ecto-Cervical Vaginal Tissue Model
	MelanoDerm Normal Human Skin Model with Melanocytes
	Melanoma Skin Model

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