Tissue Models for Drug Discovery ConferenceMatTek Corp. was invited to present at the inaugural Tissue Models for Drug Discovery Conference held November 8-9, 2004 in Boston, MA (USA).
MatTek's presentation was entitled, "Normal Human Cell-Based In Vitro Epithelial Cell Models for Drug Delivery and Toxicology Applications", and was presented by Dr. Patrick Hayden, Senior Scientist, Research and Development, MatTek Corporation.
Click on this Link to View/Download Full Presentation
(PowerPoint Presentation in PDF)
ABSTRACT:
A survey of normal human cell-based in vitro epithelial cell models will be presented. The model systems are cultured at the air-liquid interface to reconstitute in vivo-like differentiated structure and function. Models to be presented include human based skin, ocular, vaginal, gingival and airway epithelia. Drug delivery and toxicology applications of the models including emerging high-throughtput and genomic assays will be described. The validation status of the models and the validation process for regulatory and internal use will be discussed.
Conference Overview (from the Organizers):
Intact cells provide an ideal platform for measuring complex biological processes and screening for the effects of drug candidates. Such assays can:
• Monitor functions
• Analyze multiple-step pathways
• Be used to determine regulation of gene expression in response to biological and pharmacologic stimuli
• Allow identification of new targets for drug discovery
These attributes make cell-based assays powerful tools for nearly every facet of drug discovery and development, and the focus for a great deal of research effort in the biotechnology and pharmaceutical industry. To more faithfully translate the findings from basic cellular research, cell-based models need to capture both the 3-D organization and multicellular complexity of an organ, at the same time, accommodating systematic experimental intervention. These tissue-specific 3-D organotypic models have great potential for the design and development of drug therapies. Ethical, technical, and financial constraints inherent in research on human cells and tissues demand models that faithfully parallel human form and function. This meeting will identify current best practices in cell and tissue culture, development of cell and tissue based assays, and explore the potential of 3-D science in drug discovery and development.
====================
Click on This Link to Request an Electronic Copy (PDF format) of this Technical Paper
|
