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MatTek Corp. has made significant progress in the creation of Drug Delivery Research Tools based on our 15-plus years of experience producing human cell-derived, 3 dimensional, organotypic in vitro skin and corneal tissue models.
In addition to existing EpiDerm protocols and tissue configurations for transdermal drug delivery studies, the following Drug Delivery Research Tools are now available:
EpiAirway – a tracheal/bronchial tissue model used in the development of inhaled pharmaceutical formulations.
EpiVaginal - an ectocervico-vaginal model that is finding utility in the development of topically applied microbicides used in the fight against HIV.
EpiOral – a buccal (inner cheek) model finding utility as a first order approximation of permeability characteristics of drugs delivered transmucosally (absorption through buccal tissue).
Titles for several recent technical papers on these Drug Delivery Research Tools are listed below, including a hyperlink to each paper’s citation/summary on the MatTek Web site.
Full technical papers for all references are available from MatTek in PDF format. Please use our online Information/Literature Request Form to order copies (list the MatTek technical paper “TR" numbers on the form):
EPIDERM DRUG DELIVERY ADVANCES
MatTek Corp. presented 3 technical posters at the American Association of Pharmaceutical Scientists (AAPS) 2002 Annual Meeting in Toronto, Canada.
All 3 posters dealt with Transdermal Drug Delivery. Please click on the hyperlink to view a citation/ summary for that session:
BARRIER FUNCTION COMPARISON BETWEEN IN VITRO SKIN, ORAL (BUCCAL), AND OCULAR TISSUE MODELS - IMPLICATIONS FOR DRUG DELIVERY STUDIES
(MatTek TR 274)
IMPROVEMENTS IN EPIDERM, A HIGHLY DIFFERENTIATED SKIN MODEL, FOR DRUG DELIVERY STUDIES
(MatTek TR 272)
NALTREXONE ESTER PRODRUG BIOCONVERSION IN A HUMAN EPIDERMIS EQUIVALENT
(MatTek TR 273)
In addition, the following EpiDerm technical poster was presented at this year’s Society of Investigative Dermatology (SID) Meeting:
IN VITRO PERCUTANEOUS ABSORPTION USING THE MATTEK EPI-606X SKIN CONSTRUCT AND HUMAN SKIN.
(MatTek TR 294)
A recent article in Nature Biotechnology highlighted a novel method developed to identify transdermal permeability enhancers with both high efficacy and low irritation potential (IP). The method used to determine IP was the EpiDerm Skin Irritation Measurement System.
DISCOVERY OF TRANSDERMAL PENETRATION ENHANCERS BY HIGH-THROUGHPUT SCREENING
(MatTek TR 319)
EPIAIRWAY DRUG DELIVERY ADVANCES
EpiAirway tracheal/bronchial tissues have proven to be a highly reliable model for drug permeation of inhaled pharmaceutical formulations. Established protocols for measuring toxicity, transepithelial electrical resistance and drug permeation enable rapid pre-clinical optimization of candidate formulations.
Recent technical highlights include:
REPRODUCIBILITY OF EPIAIRWAY, A DIFFERENTIATED AIRWAY TISSUE MODEL FOR PRE-CLINICAL DRUG DEVELOPMENT STUDIES
(MatTek TR 298)
EFFECTS OF ENHANCERS ON MACROMOLECULES FORMULATIONS ON MEMBRANE PENETRATION, CELL VIABILITY AND RESISTANCE USING EPI-AIRWAY TISSUE MODEL
(MatTek TR 244)
PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL
(MatTek TR 243)
There has also been nasal drug delivery research performed using the EpiAirway model at a major U.S. university (SUNY Stony Brook, NY). A summary and a poster (in PDF format) of that research are available below with the author's permission:
EVALUATION OF THE PENETRATION AND CYTOTOXIC EFFECTS OF DRUG FORMULATIONS ON AN IN VITRO NASAL MUCOSAL MODEL
AN IN VITRO MODEL FOR THE RAPID SCREENING OF POTENTIAL COMPONENTS AND FORMULATIONS FOR NASAL DRUG DELIVERY
(MatTek TR 271)
EPIVAGINAL DRUG DELIVERY ADVANCES
The following paper was presented at a symposium entitled: "Topical Microbicides Development and Evaluation Workshop," at The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Washington, D.C.:
RECONSTRUCTED HUMAN VAGINAL-ECTOCERVICAL TISSUE MODELS
(MatTek TR 291)
EPIORAL DRUG DELIVERY ADVANCES
EpiOral is MatTek’s most recent addition to the growing family of human cell-based, 3-dimensional, organotypic tissue models. An overview of the barrier function characteristics of EpiOral vs. (in particular) EpiDerm is given in the following paper:
BARRIER FUNCTION COMPARISON BETWEEN IN VITRO SKIN, ORAL (BUCCAL), AND OCULAR TISSUE MODELS - IMPLICATIONS FOR DRUG DELIVERY STUDIES
(MatTek TR 274)
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Technical papers for all technical posters are available from MatTek in PDF format. Please complete the MatTek Information/Literature Request Form or contact MatTek to receive your copy. Please use the MatTek "TR" number to order the paper(s) of your choice.
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