New MatTek Technical References April 2009

Listed below are the MatTek In Vitro Product Technical References added to the Web site in APRIL 2009. Click on the technical reference TITLE to review full citation information as well as a detailed summary.

• HUMAN PARAINFLUENZA VIRUS INFECTION OF THE AIRWAY EPITHELIUM: THE VIRAL HEMAGGLUTININ-NEURAMINIDASE REGULATES FUSION PROTEIN ACTIVATION AND MODULATES INFECTIVITY.
  
  SUMMARY:
  This study by researchers at Weill Medical College of Cornell University, the Australian Animal Health Laboratory/CSIRO, Ohio State University College of Veterinary Medicine and Mount Sinai Hospital demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent provides an ideal system for assessing the interplay of host cell and viral factors in pathogenesis (human parainfluenza virus infection of airway epithelium), and for screening for inhibitory molecules that would be effective in vivo.
  
  
  
• FOLLOW-UP VALIDATION OF THE EPIDERM SKIN IRRITATION TEST (SIT): RESULTS OF A MULTI-CENTRE STUDY OF TWENTY REFERENCE TEST SUBSTANCES.
  
  SUMMARY:
  This multi-center validation study performed by scientists at BfR (ZEBET), BASF SE, the Institute for In Vitro Sciences, Inc., the Centre for Alternative and Complementary Methods to Animal Testing (zet–LSL) and MatTek Corp. demonstrated that the modified Skin Irritation Test (SIT) based on MatTek’s EpiDerm in vitro human skin tissue equivalent can be used to as stand alone assay for the prediction of skin irritating and non-irritating test substances.