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USE OF EPIDERM FULL THICKNESS TISSUE FOR ANTI-AGING STUDIES.
Gruber, V., et al.
Arch Personal Care Products L.P., South Plainfield, NJ and Bio-Innovation Laboratories, McKinney, TX.
Keywords: Anti-aging, Anti-wrinkle effect, Anti-wrinkle properties, Biodynes Extracellular Matrix Promoting, Biodynes® EMPP, Collagens, EFT-200, EPI-200, Elastic fibers, Elastin, EpiDerm, EpiDerm-FT, EpiDermFT, EpiOcular, Fibronectin, Full Thickness Tissue Model, Glycosaminoglycans (GAGs), In vitro test systems, Laminin, Line minimizing, OCL-200, Peptone (Biodynes EMPP), Photoaging, Proteoglycans, Saccharomyces cerevisiae (Baker’s Yeast), Skin elasticity, Skin smoothing, Stress response, Toxicological testing, Wrinkle reduction, Wrinkles
Endpoints: Anti-wrinkle, Elastin production, Line mimimizing
Materials Tested: Biodynes® EMPP, Biodynes®TRF®, Na Ascorbate (0.1%)
Summary:
The extracellular matrix of human skin is compromised of collagens, elastic fibers (of which elastin is a major component), and basement membrane associated macromolecules such as proteoglycans, fibronectin, and laminin. As skin ages, both intrinsically and through photoaging, the aging process is manifested on the skin through sagging, wrinkles, and a loss of elasticity. In addition to these visible changes, the extracellular matrix deteriorates. Cosmetic formulations attempt to visibly improve or reverse these signs of aging.
Orally and topically applied glycosaminoglycans (GAGs) and proteoglycans can stimulate the production of elastin. Biodynes Extracellular Matrix Promoting Peptone (Biodynes EMPP) is a new biofermentation lysate that has been developed to stimulate elastin formation.
Using the MatTek Full Thickness EpiDerm tissue model (EFT-200), scientists at Arch Personal Care Products have demonstrated that Biodynes EMPP increases the soluble elastin content of the skin tissue by 15%. In addition, in vivo wrinkle studies on 10 subjects showed that Biodynes EMPP decreased the volume, depth, and complexity of wrinkles by 12%, 11%, and 43%, respectively over a 28 day period.
The Biodynes EMPP was also determined to be non-irritating in both the MatTek EpiOcular (OCL-200) and EpiDerm (EPI-200) in vitro test systems.
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EpiDermFT Data Sheet
EpiDermFT Specifications
EpiDermFT Technical References
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EpiDerm Data Sheet
EpiDerm Specifications
EpiDerm Technical References
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EpiOcular Data Sheet
EpiOcular Specifications
EpiOcular Technical References
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