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DRUG PERMEABILITY ACROSS BOVINE RESPIRATORY TISSUES COMPARED TO A HUMAN TRACHEO/BRONCHIAL CELL CULTURE (EPIAIRWAY™ SYSTEM).
Chemuturi1, N., Donovan1, M., Klausner2, M., and Hayden2, P.
1College of Pharmacy, University of Iowa, Iowa City, IA. 2MatTek Corporation, Ashland, MA.
Poster presented at the American Association of Pharmaceutical Scientists (AAPS), Salt Lake City, UT, October 26-30, (2003).
Summary: The past three decades have seen the emergence of the nasal mucosa as a viable alternative route for drug delivery. The availability of over 15 drugs meant for systemic action is a testament to its rapidly growing popularity. However, the absence of a good in vitro model precludes the rapid screening of suitable drug compounds and the investigation of molecular processes involved in nasal drug delivery. Although animal-derived nasal mucosal explants are popular, comparisons of their transport properties to humans has not been studied. Currently, a cell culture system derived from normal human tracheal/bronchial epithelial cells (EpiAirway™ system) is being investigated for its utility in drug transport studies.
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EpiAirway Data Sheet
EpiAirway Specifications
EpiAirway Technical References
Applications: Drug delivery - intranasal
Keywords: Active transport, Bovine respiratory mucosa, Bovine respiratory tissue, Diffusion medium, Distribution coefficient, Drug delivery, Drug permeability, Drug transport, EpiAirway, Flux, Human traceho/bronchial cell culture, Lead optimization, Nasal drug delivery, Nasal mucosa, Normal human tracheal/bronchial epithelial cells, Permeability, Rapid screening, Respiratory tract, Tracheal bronchial epithelial cells
Endpoints: Flux, HPLC, Permeability, TEER
Materials Tested: Cefazolin HCl, Dextromethorphan HBr, Dopamine HCl, Hydroxyzine 2HCl, Naloxone HCl, Phenol Red, Propranolol HCl, Quinidine HCl, Tetracaine HCl, Triprolidine HCl |
